Dr. Catalona, co-author of a new study on lowering PSA threshold for biopsy to 2.5, was quoted in the Wall Street Journal (March 23, 2004), "To Improve Prostate-Cancer Detection, Doctors Change Approach to Testing."
In the article, Dr. Catalona said that for many men, lowering the threshold simply means they'll get a biopsy sooner rather than later. In a 12-year, 36,000-man study in St. Louis, doctors charted rising PSA scores for a number of men who weren't given a biopsy or diagnosed with cancer until their score finally hit 4.
"These men would look at their PSA record and say, 'The writing's been on the wall for a long time. Why didn't we do that biopsy earlier?"